## Abstract An efficient preparation of __N__‐succinimidyl 4‐[^18^F]fluorobenzoate ([^18^F]SFB) based on a convenient three‐step, one‐pot procedure is described. [^18^F]Fluorination of the precursor ethyl 4‐(trimethylammonium triflate)benzoate gave ethyl 4‐[^18^F]fluorobenzoate. Saponification of t
Module-assisted synthesis of the bifunctional labelling agent N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB)
✍ Scribed by P. Mäding; F. Füchtner; F. Wüst
- Book ID
- 103816776
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 271 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0969-8043
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## Abstract The acylation reagent [^18^F]__N__‐succinimidyl‐4‐fluorobenzoate (^18^F‐SFB) has been prepared using a new two‐step approach. The starting material __p‐__[^18^F]fluorobenzaldehyde (^18^F‐FBA) was obtained by an improved radiosynthesis with a decay‐corrected radiochemical yield of 66±6 %
## Abstract A fully automated synthesis of __N__‐succinimidyl 4‐[^18^F]fluorobenzoate ([^18^F]SFB) was carried out by a convenient three‐step, one‐pot procedure on the modified TRACERlab FX~FN~ synthesizer, including [^18^F]fluorination of ethyl 4‐(trimethylammonium triflate)benzoate as the precurs