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Synthesis of N -Phosphonamidothionate Derivatives of Glutamic Acid

✍ Scribed by Lu, Haiyan; Mlodnosky, Karyn L.; Dinh, Trang T.; Dastgah, Azar; Lam, Vinh Q.; Berkman, Clifford E.

Book ID
126165790
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
56 KB
Volume
64
Category
Article
ISSN
0022-3263

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## Abstract Novel aryl N‐phosphonamidothionate derivatives of nucleosides as membrane‐soluble prodrugs of bioactive free nucleotides have been prepared by phosphochloridothioate chemistry. Unprotected nucleosides, for example uridine and adenosine, were used; phosphorylation took place selectively