Synthesis of 14C-methotrexate: (N-[p-[[2
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M. G. Nair; Charles M. Baugh
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Article
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1977
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John Wiley and Sons
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French
β 270 KB
## Abstract A simple and general method for the synthesis of folate analogs labeled in the glutamate moiety with ^14^C is described. The synthesis makes use of the trimethylsilyl derivative of Lβglutamic acid 8 for the coupling reaction with the activated pteroate analogs. Deprotection under mild c