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Synthesis of N-[p-[[(2-amino-3,4-diliydro-4-thioxo-6-pteridinyl)methyl]-methylamino]benzoyl]-l-glutamic acid (N10-methyl-4-thiofolic acid) and related compounds

✍ Scribed by Robert D. Elliott; Carroll Temple Jr.; Jerry L. Erye; John A. Montgomery


Book ID
112123094
Publisher
Journal of Heterocyclic Chemistry
Year
1973
Tongue
English
Weight
94 KB
Volume
10
Category
Article
ISSN
0022-152X

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✍ M. G. Nair; Charles M. Baugh πŸ“‚ Article πŸ“… 1977 πŸ› John Wiley and Sons 🌐 French βš– 270 KB

## Abstract A simple and general method for the synthesis of folate analogs labeled in the glutamate moiety with ^14^C is described. The synthesis makes use of the trimethylsilyl derivative of L‐glutamic acid 8 for the coupling reaction with the activated pteroate analogs. Deprotection under mild c