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Synthesis of tritiated N-[4-(2,4-diaminopteridine-6-methyl)-3,4-dihydro-2H-1,4-benzothiazine-7-carbonyl]-L-homo glutamic acid (MX-68)

✍ Scribed by Hiroharu Matsuoka; Toshio Kuroki; Keiichi Yano; Yasuhisa Takeda


Publisher
John Wiley and Sons
Year
1997
Tongue
French
Weight
335 KB
Volume
39
Category
Article
ISSN
0022-2135

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Two new natural products, N- (2-methyl-3-oxodec-8-enoyl)corresponding acid chloride, in order to acylate Meldrum's acid. Subsequent aminolysis with pyrrolidine, followed by 2-pyrroline (2) and 2-(hept-5-enyl)-3-methyl-4-oxo-6,7,8,8atetrahydro-4H-pyrrolo[2,1-b]-1,3-oxazine (3), have been methylation