Synthesis of N -Methyl Secondary Amines
โ Scribed by Kumpaty, Hephzibah J.; Williamson, John S.; Bhattacharyya, Sukanta
- Book ID
- 121373631
- Publisher
- Taylor and Francis Group
- Year
- 2003
- Tongue
- English
- Weight
- 175 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0039-7911
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๐ SIMILAR VOLUMES
A new rapid high yield synthesis of radiolabeled N'-(4-11C-methyl)imipramine has been developed using a reductive-carboxylation approach, in which 11CO2 is reacted with either N'-trimethylsilyldesimipramine or N'-lithium derivative of desimipramine, followed by lithium aluminum hydride reduction, to
Kinetic studies established that the monomethylation of a primary amine leads to significantly higher reaction rates with glycidyl ethers. The relative rates for approximately 25 amines were determined in an alcohol solvent under pseudo-firstorder conditions (excess epoxy). The rates were referenced