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Rapid reductive-carboxylation of secondary amines, one pot synthesis of N′-(4-11C-methyl)imipramine

✍ Scribed by Siya Ram; Richard E. Ehrenkaufer; Douglas M. Jewett

Book ID: 103919626
Publisher: Elsevier Science
Year: 1986
Weight: 422 KB
Volume: 37
Category: Article
ISSN: 0883-2889
DOI: 10.1016/0883-2889(86)90094-8

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✦ Synopsis

A new rapid high yield synthesis of radiolabeled N'-(4-11C-methyl)imipramine has been developed using a reductive-carboxylation approach, in which 11CO2 is reacted with either N'-trimethylsilyldesimipramine or N'-lithium derivative of desimipramine, followed by lithium aluminum hydride reduction, to give no carrier added or carrier added 11C-labeled imipramine respectively. The final product is characterized by chromatographic and spectroscopic methods.

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