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Synthesis of N-[methyl-11C]hydromorphone by using multivariate strategies for optimization of radiochemical yields

✍ Scribed by Annika Rimland; Göran Bergson; Ulf Obenius; Stefan Sjöberg; Bengt Långström


Book ID
103919936
Publisher
Elsevier Science
Year
1987
Weight
391 KB
Volume
38
Category
Article
ISSN
0883-2889

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## Abstract 2β‐Carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐^11^C‐methyl]tropane, a potent inhibitor of dopamine transport, was prepared by N‐methylation of the appropriate nor‐methyl precursor in DMF with [^11^C]iodomethane. After derivatization of unreacted precursor with a long chain acyl halide, the rad