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Synthesis of N-Carboxy-α-amino Acid Anhydrides

✍ Scribed by Dr. D. Konopińska; Dr. I. Z. Siemion

Publisher
John Wiley and Sons
Year
1967
Tongue
English
Weight
122 KB
Volume
6
Category
Article
ISSN
0044-8249

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📜 SIMILAR VOLUMES

Stepwise synthesis of oligopeptides with
Stepwise synthesis of oligopeptides with N-carboxy α-amino acid anhydrides
✍ Oshio Iwakura; Keikichi Uno; Masanao Oya; Ryoichi Katakai 📂 Article 📅 1970 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 365 KB

## Abstract Oligopeptides were synthesized in high yields by the controlled coupling reaction of __N__‐carboxy α‐amino acid anhydrides (NCA's) with amino acid and peptide sodium salts in the heterogeneous reaction medium of acetonitrile–water which contained sodium carbonate. In this solvent, it co

Synthesis of N-protected peptides by the
Synthesis of N-protected peptides by the o-nitrophenylsulfenyl group using o-nitrophenylsulfenyl N-carboxy α-amino acid anhydrides
✍ Ryoichi Katakai; Masanao Oya 📂 Article 📅 1975 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 482 KB

## Abstract __N__‐protected peptides, which are important intermediates as a carboxyl component in the fragment condensation method, have been prepared in high yields by the reaction of __o__‐nitrophenylsulfenyl (Nps) __N__‐carboxy α‐amino acid anhydrides with unprotected peptides and amino acids i

Stepwise synthesis of oligopeptides with
Stepwise synthesis of oligopeptides with N-carboxy α-amino acid anhydrides. II. Oligopeptides with some polar side chains
✍ Ryoichi Katakai; Masanao Oya; Keikichi Uno; Yoshio Iwakura 📂 Article 📅 1971 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 446 KB

The reaction of NCA's with some amino acids having a nucleophilic functional group on the side chain was studied in a heterogeneous reaction medium (acetonitrile-water). Glutamic acid and aspartic acid, having a free carboxyl group on the side chain, were successfully used to synthesize oligopeptide

Polymerization of α-amino acid N-carboxy
Polymerization of α-amino acid N-carboxy anhydrides in N,N-dimethylformamide
✍ Robert E. Nylund; Wilmer G. Miller 📂 Article 📅 1964 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 223 KB

The polymerization of -y-benzyl+glutamate NCA initiated by n-hexylamine in DMF proceeds with two successive propagation r a h whose ratio is about 1.5. The onset of the increase in rate of propagation occurred a t a DP, of 7-14, which waa independent of initiator to anhydride ratio and anhydride con

Circular dichroism studies on the polyme
Circular dichroism studies on the polymerization of N-carboxy α-amino acid anhydride
✍ Toshihiro Akaike; Tetsuya Makino; Shohei Inoue; Teiji Tsuruta 📂 Article 📅 1974 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 479 KB

## Abstract The D and L copolymerizations of __N__‐carboxy γ‐benzyl glutamate anhydride (NCA) were carried out in a homogeneous solution with various D/L ratios, initiated by either __n__‐butylamine or sodium methoxide, and were followed directly by circular dichroism (CD) to observe the behavior o