𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Polymerization of α-amino acid N-carboxy anhydrides in N,N-dimethylformamide

✍ Scribed by Robert E. Nylund; Wilmer G. Miller

Publisher
Wiley (John Wiley & Sons)
Year
1964
Tongue
English
Weight
223 KB
Volume
2
Category
Article
ISSN
0006-3525

No coin nor oath required. For personal study only.

✦ Synopsis

The polymerization of -y-benzyl+glutamate NCA initiated by n-hexylamine in DMF proceeds with two successive propagation r a h whose ratio is about 1.5. The onset of the increase in rate of propagation occurred a t a DP, of 7-14, which waa independent of initiator to anhydride ratio and anhydride concentration and not a result of anhydride impurities. The increase in rate is likely a result of a conformational change in the polymer a t a DP, of 7-14.

📜 SIMILAR VOLUMES

Stepwise synthesis of oligopeptides with
Stepwise synthesis of oligopeptides with N-carboxy α-amino acid anhydrides
✍ Oshio Iwakura; Keikichi Uno; Masanao Oya; Ryoichi Katakai 📂 Article 📅 1970 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 365 KB 👁 1 views

## Abstract Oligopeptides were synthesized in high yields by the controlled coupling reaction of __N__‐carboxy α‐amino acid anhydrides (NCA's) with amino acid and peptide sodium salts in the heterogeneous reaction medium of acetonitrile–water which contained sodium carbonate. In this solvent, it co

Circular dichroism studies on the polyme
Circular dichroism studies on the polymerization of N-carboxy α-amino acid anhydride
✍ Toshihiro Akaike; Tetsuya Makino; Shohei Inoue; Teiji Tsuruta 📂 Article 📅 1974 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 479 KB 👁 1 views

## Abstract The D and L copolymerizations of __N__‐carboxy γ‐benzyl glutamate anhydride (NCA) were carried out in a homogeneous solution with various D/L ratios, initiated by either __n__‐butylamine or sodium methoxide, and were followed directly by circular dichroism (CD) to observe the behavior o

Synthesis of N-protected peptides by the
Synthesis of N-protected peptides by the o-nitrophenylsulfenyl group using o-nitrophenylsulfenyl N-carboxy α-amino acid anhydrides
✍ Ryoichi Katakai; Masanao Oya 📂 Article 📅 1975 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 482 KB 👁 1 views

## Abstract __N__‐protected peptides, which are important intermediates as a carboxyl component in the fragment condensation method, have been prepared in high yields by the reaction of __o__‐nitrophenylsulfenyl (Nps) __N__‐carboxy α‐amino acid anhydrides with unprotected peptides and amino acids i

Stepwise synthesis of oligopeptides with
Stepwise synthesis of oligopeptides with N-carboxy α-amino acid anhydrides. II. Oligopeptides with some polar side chains
✍ Ryoichi Katakai; Masanao Oya; Keikichi Uno; Yoshio Iwakura 📂 Article 📅 1971 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 446 KB

The reaction of NCA's with some amino acids having a nucleophilic functional group on the side chain was studied in a heterogeneous reaction medium (acetonitrile-water). Glutamic acid and aspartic acid, having a free carboxyl group on the side chain, were successfully used to synthesize oligopeptide