✦ LIBER ✦

Synthesis of N-[1-13C]caproyl-N′-phenylthiourea

✍ Scribed by Corina Anca Simion; Cristian Postolache; Calin Deleanu; Ileana Chirtoc; Catalina Mihaela Barna; Ioana Bally; Alexandru T. Balaban

Publisher: John Wiley and Sons
Year: 2004
Tongue: French
Weight: 82 KB
Volume: 47
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.859

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

An optimal synthesis of N‐[1‐^13^C]caproyl‐N′‐phenylthiourea with isotopic enrichment 82% is described, starting from barium [^13^C]carbonate, using five synthetic steps. Yields were 95% relative to caproyl chloride and 46% relative to barium carbonate. Oxidation of the title compound with manganese dioxide yields the corresponding ureide. Structural similarities with anticonvulsants such as phenacemide make N‐caproyl‐N′‐phenylthiourea an interesting model compound. Copyright © 2004 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Comparison of the thiocarbonyl13C NMR re

Comparison of the thiocarbonyl13C NMR resonances of N-phenylthioureas, N-phenyl thiocarbamates and N-phenyl dithiocarbamates

✍ Jeffrey J. Ares; Thomas G. Urchek; Charles W. Palmer JR; Duane D. Miller 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 166 KB

Synthesis of [2-13C, 2-14C]2-aminoethano

Synthesis of [2-13C, 2-14C]2-aminoethanol, [1-13C, 1-14C]2-chloroethylamine, N,N′-bis([1-13C, 1-14C]2-chloroethyl)-N-nitrosourea(BCNU) and N-([1-13C, 1-14C]2-chloroethyl)-N-nitrosourea(CNU)

✍ Ramani Narayan; Ching-Jer Chang 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 311 KB

## Abstract [2‐^13^C, 2‐^14^C]2‐Aminoethanol hydrochloride was prepared in good yield from Na\*CN in a two step sequence by first converting the Na\*CN to OHCH~2~\*CN and then reducing the nitrile directly with a solution of borane‐tetrahydrofuran complex. The reaction procedure was simple and the

Synthesis of [N-methyl-13C]clarithromyci

Synthesis of [N-methyl-13C]clarithromycin

✍ Tomoko Murase; Masahiro Kajiwara 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 81 KB

Infrared Spectrum of15N13C13C15N near 21

Infrared Spectrum of15N13C13C15N near 2100 cm−1

✍ Wolfgang Quapp; Arthur Maki; Stefan Klee; Georg Mellau 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 158 KB

The high resolution infrared spectrum of the linear centro-symmetric molecule 13 C 2 15 N 2 (cyanogen) has been measured in the region from 1950 to 2150 cm 01 . The n 3 fundamental band and the difference band n 1 -n 5 were observed in that region. Hot-band transitions arising from the n 5 , 2n 5 ,

Synthesis of 13C labeled n-alkylchlorosi

Synthesis of 13C labeled n-alkylchlorosi lanes

✍ R. K. Gilpin; M. E. Gangoda 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 191 KB

1 3 e n r i c h e d n -a l k y l c h l o r o s i l a n e s w i t h l a b e l i nc o r p o r a t i o n a t s e l e c t i v e p o s i t i o n s a l o n g t h e a l k y l c h a i n s . Compounds w h i c h w e r e p r e p a r e d w e r e : n -n o n y l t r i c h l o r o s i 1 a n e -1 -' 3 C n -d o d e

Synthesis of n-butyl [3-13C]acrylate

✍ J. Šmejkal; V. Hanuš; I. Linhart; T. Elbert 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 184 KB

## Abstract A four step synthesis of n‐butyl [3‐^13^C]acrylate from [^13^C]methyl iodide is described. The procedure involves methylation of butyl acetoacetate, subsequent bromination, alkaline cleavage and, finally, dehydrobromination using cyclohexyldimethylamine. The overall yield was 5%.