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Synthesis of Modified Oligonucleotides and Production of Duplexes With Covalently Linked Chains

โœ Scribed by Antsypovich, S. I.; Oretskaya, T. S.; Volkov, E. M.; Romanova, E. A.; Tashlitsky, V. N.; Blumenfeld, M.; Shabarova, Z. A.

Book ID
111897488
Publisher
Taylor and Francis Group
Year
1996
Tongue
English
Weight
595 KB
Volume
15
Category
Article
ISSN
0732-8311

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Since synthetic oligonucleotides complementary to mRNA sequences were shown to inhibit Rous sarcoma virus replication, [1] oligonucleotide chemists have synthesized all types of analogues to render oligonucleotides suitable as antisense agents. In this context, platinated oligonucleotides have been