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Synthesis of methyl 1-(3,4-dichlorobenzyl)-hexahydro-2,3-dioxo-4-pyridinecarboxylate

✍ Scribed by Thomas J. Schwan; Joseph E. Gray; George C. Wright

Book ID: 102409877
Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 208 KB
Volume: 68
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600680442

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✦ Synopsis

Methyl 1-(3,4-dichlorobenzyl)-hexahydro-2,3-dioxo-4-pyridinecarboxylate was prepared by alkylation of methyl hexahydro-2,3-dioxo-4-pyridinecarboxylate with alpha,3,4-trichlorotoluene. The compound showed significant antifungal activity when challenged by a spectrum of pathogenic yeast species in a minimum inhibitory concentration test. It was active against some dermatophytic fungi and Aspergillus niger.

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