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Synthesis of 5-Alkyl-1,3-bis[2-hydroxy-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)propyl]-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-diones

✍ Scribed by V. P. Krivonogov; G. G. Kozlova; E. A. Belaya; G. A. Sivkova; L. V. Spirikhin; I. B. Abdrakhmanov; V. V. Plechev


Book ID
111609203
Publisher
SP MAIK Nauka/Interperiodica
Year
2004
Tongue
English
Weight
56 KB
Volume
40
Category
Article
ISSN
1070-4280

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The title compound, C 14 H 16 N 2 O 4 S, was synthesized by the reaction of 4-hydroxy-3-methoxybenzaldehyde, thiourea and methyl 3-oxobutanoate in ethanol under reflux. The crystal structure is stabilized mainly through intermolecular N-HÁ Á ÁS and O-HÁ Á ÁO hydrogen bonds. The tetrahydropyrimidin-2

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In the title compound, C 15 H 18 N 2 O 4 S, the packing is consolidated by an intra/intermolecular bifurcated O-HÁ Á Á(O,O) and intermolecular N-HÁ Á ÁS hydrogen bonds. The tetrahydropyrimidin-2-one ring is twisted. ## Related literature For background, see: Kappe (1993). ## Experimental Cryst