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Synthesis of (+/-) Mappicine and Mappicine Ketone.

✍ Scribed by Kevin E. Henegar; Ted A. Baughman

Book ID
101953447
Publisher
John Wiley and Sons
Year
2004
Weight
164 KB
Volume
35
Category
Article
ISSN
0931-7597

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Synthesis of (+/-) mappicine and mappici
Synthesis of (+/-) mappicine and mappicine ketone
✍ Kevin E. Henegar; Ted A. Baughman πŸ“‚ Article πŸ“… 2003 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 46 KB

## Abstract Mappicine and mappicine ketone are camptothecin analogs of interest as antiviral agents. A novel synthesis of these compounds is described using a Friedlander condensation. The requisite ketone is prepared __via__ a regioselective __ortho__‐directed metallation/alkylation of a trisubsti