ChemInform Abstract: Synthesis of (S)-Mappicine and Mappicine Ketone via Radical Cascade Reaction of Isonitriles.
β Scribed by H. JOSIEN; D. P. CURRAN
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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Synthetic Studies on Natural Products. Part 9. Chemoenzymatic Transformation of the Natural Antitumor Alkaloid 20-O-Acetylcamptothecin to Mappicine Ketone and (S)-Mappicine. -The naturally occurring alkaloid (I) is converted to mappicine ketone (V), an antiviral lead compound, and its natural reduc
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