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ChemInform Abstract: Synthetic Studies on Natural Products. Part 9. Chemoenzymatic Transformation of the Natural Antitumor Alkaloid 20-O-Acetylcamptothecin to Mappicine Ketone and (S)-Mappicine.

✍ Scribed by Biswanath Das; P. Madhusudhan; B. Venkataiah

Publisher: John Wiley and Sons
Year: 2010
Weight: 29 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199949190

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✦ Synopsis

Synthetic Studies on Natural Products. Part 9. Chemoenzymatic Transformation of the Natural Antitumor Alkaloid 20-O-Acetylcamptothecin to Mappicine Ketone and (S)-Mappicine.

-The naturally occurring alkaloid (I) is converted to mappicine ketone (V), an antiviral lead compound, and its natural reduction product (S)-mappicine (VI) (some yields given in gram).

-(DAS, BISWANATH; MADHUSUDHAN,

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