Synthesis of macrolide antibiotics. 2. Synthesis of the C9-C13 segments of erythronolides A, B and oleandonolide
โ Scribed by N.K. Kochetkov; A.F. Sviridov; M.S. Ermolenko; N.D. Zelinsky
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 234 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The Cg-C,3 segments of some l+membered macrolide antibiotics have
๐ SIMILAR VOLUMES
The C,-C6 segment of a number of 14-membered macrolide antibiotics have been synthesized started from levoglucosan.
The C( 1)-C(9) segment 3 of the macrolides epothilon A and B 1, two new cytotoxic natural products, has been synthesized in a direct manner. Key steps in the synthesis are a stereoselective aldol reaction of 6 and 7 and a Brown allylation of 9.
The Ct-Ct3 segment 6 of concanamycin A (1) was prepared by a highly stereocontrolled route (87% overall ds) in 16 steps from the ester 9. Key steps are the one-pot aldol/reduction, 8 + 12, and the HWB reaction, 18 + 19 + 6.8 1997 Elsevier Science Ltd.