Synthesis of Lithocholic Acid Derivatives as Proteasome Regulators
β Scribed by Dang, Zhao; Jung, Kathy; Qian, Keduo; Lee, Kuo-Hsiung; Huang, Li; Chen, Chin-Ho
- Book ID
- 118748088
- Publisher
- American Chemical Society
- Year
- 2012
- Tongue
- English
- Weight
- 302 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1948-5875
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## Abstract A convenient synthesis is reported of lithocholic acid labelled in high isotopic purity with two atoms of deuterium at Cβ11. Incorporation of deuterium is achieved by baseβcatalyzed equilibration of a 12βoxo bile acid in heavy water. The product is converted __in situ__ into its tosylhy