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Synthesis of lipopeptides using hydrazone chemical ligation

✍ Scribed by Melnyk, O. ;Bossus, M. ;David, D. ;Rommens, C. ;Gras-Masse, H.

Book ID
110893714
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
649 KB
Volume
52
Category
Article
ISSN
1397-002X

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An oligonucleotide was functionalized on the solid-phase by a tartaramide moiety, which could be converted efficiently in solution into a glyoxylyl group following a mild periodic oxidation. The glyoxylyl-oligonucleotide was found to be very stable upon storage and was successfully engaged in hydraz