𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of oligonucleotide–peptide conjugates using hydrazone chemical ligation

✍ Scribed by Nathalie Ollivier; Christophe Olivier; Catherine Gouyette; Tam Huynh-Dinh; Hélène Gras-Masse; Oleg Melnyk

Book ID
104232356
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
162 KB
Volume
43
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

An oligonucleotide was functionalized on the solid-phase by a tartaramide moiety, which could be converted efficiently in solution into a glyoxylyl group following a mild periodic oxidation. The glyoxylyl-oligonucleotide was found to be very stable upon storage and was successfully engaged in hydrazone ligation with an a-hydrazino acetyl peptide.

📜 SIMILAR VOLUMES

Native chemical ligation in the synthesi
Native chemical ligation in the synthesis of internally modified oligonucleotide–peptide conjugates
✍ Franziska Diezmann; Hendrik Eberhard; Oliver Seitz 📂 Article 📅 2010 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 248 KB 👁 2 views

## Abstract Peptide–oligonucleotide conjugates have frequently been synthesized to improve cellular delivery of antisense or antigene compounds, to allow the immobilization of peptide and protein conjugates on DNA arrays, or to decorate nucleic acid architectures with peptide functions. In such app