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Synthesis of linear tuftsin analogues modified at the ε-amino group of lysine
✍ Scribed by Magdalena Kukowska-Kaszuba; Krystyna Dzierzbicka; Zbigniew Maćkiewicz
- Book ID
- 108285122
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 192 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The synthesis of sphinganine analogues modified in the head group is reported. The target compounds are efficiently prepared by means of the Henry reaction. Synthesis and results of preliminary investigations of the derivatives as potential inhibitors of sphingolipid biosynthesis are presented.
In solid-phase peptide synthesis, a side-reaction consisting of the premature and undesired removal of the Fmoc group has been detected. This can be caused by a primary amine of sufficient basicity, such as the o-amino of the Lys, present in the peptide resin. This side-reaction, which is not promot