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Synthesis of sphinganine analogues modified in the head group

✍ Scribed by Thomas Kolter; Gerhild van Echten-Deckert; Konrad Sandhoff

Book ID
104204734
Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
642 KB
Volume
50
Category
Article
ISSN
0040-4020

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✦ Synopsis

The synthesis of sphinganine analogues modified in the head group is reported. The target compounds are efficiently prepared by means of the Henry reaction. Synthesis and results of preliminary investigations of the derivatives as potential inhibitors of sphingolipid biosynthesis are presented.

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