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Enzymatic formation of an isopeptide bond involving the ε-amino group of lysine

✍ Scribed by Hiroshi Kitaguchi; Dar-Fu Tai; Alexander M. Klibanov


Book ID
104216817
Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
136 KB
Volume
29
Category
Article
ISSN
0040-4039

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✦ Synopsis


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In solid-phase peptide synthesis, a side-reaction consisting of the premature and undesired removal of the Fmoc group has been detected. This can be caused by a primary amine of sufficient basicity, such as the o-amino of the Lys, present in the peptide resin. This side-reaction, which is not promot