Synthesis of L-ornithines stereospecifically deuterated at C-3
β Scribed by Jack E. Baldwin; Kirsten D. Merritt; Christopher J. Schofield
- Book ID
- 104215885
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 130 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
## Abstract 4β[^2^H~2~]βLβglutamic acid was prepared in excellent yield by enzymatic reductive amination of 4β[^2^H~2~]β2βketoglutaric acid. The synthesis of stereospecifically deuterated (4 R) and (4 S)β[4β^2^H~2~]βLβglutamic acids from (2 RS, 4 S) and (2 RS, 4 R)β4βhydroxyglutamic acids, involvin
No-carrier-added L-[5-11C]ornithine was synthesized in 25-40% radiochemical yield in a synthesis time of 50 min (EOB) and a specific ac vity >2.1 Ci/umol by the displacement reaction of potassium ['fC]cyanide with the functionally protected y- bromohomoserine followed by selective reduction of the [