Synthesis of a monocyclic ?-lactam stereospecifically labelled at C-4
β Scribed by Gani, David; Young, Douglas W.; Carr, David M.; Poyser, J. Philip; Sadler, Ian H.
- Book ID
- 121274941
- Publisher
- Royal Society of Chemistry
- Year
- 1983
- Weight
- 513 KB
- Volume
- 0
- Category
- Article
- ISSN
- 1472-7781
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π SIMILAR VOLUMES
## Abstract 4β[^2^H~2~]βLβglutamic acid was prepared in excellent yield by enzymatic reductive amination of 4β[^2^H~2~]β2βketoglutaric acid. The synthesis of stereospecifically deuterated (4 R) and (4 S)β[4β^2^H~2~]βLβglutamic acids from (2 RS, 4 S) and (2 RS, 4 R)β4βhydroxyglutamic acids, involvin
A ~ZC and ~5N-iabeled lactam analog of a naturally occurring GM4 lactone glycolipid was synthesized in a convergent manner. The 13C-labels in the sialic acid portion of the molecule were derived from uniformly 13C-labeled pyruvate, and the ISN was introduced using a sulfonylamidoglycosylation reacti