✍ Scribed by P. Smid; D. Noort; H. J. G. Broxterman; N. C. R. van Straten; G. A. van der Marel; J. H. van Boom
No coin nor oath required. For personal study only.
L‐Glucose derivatives are prepared by two different routes. The first involves a modification of the previously reported multi‐step approach by Shiozaki^8^, starting from a D‐glucurono‐1,5‐lactone derivative, resulting in the isolation of 2,3,4,6‐tetra‐O‐benzyl‐L‐glucopyranose. The other route comprises the synthesis of penta‐O‐acetyl‐L‐glucopyranose via a highly stereoselective addition of [(phenyldimethylsilyl)methyl]magnesium chloride with 2,3,5‐tri‐O‐benzyl‐L‐arabinofuranose.
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## Abstract A total synthesis of L‐(+)‐swainsonine, a potent and specific inhibitor of naringinase, along with the syntheses of six unnatural indolizidine azasugars are reported by starting from D‐glucose. L‐(+)‐Swainsonine was synthesized in 14 steps in 17 % overall yield. Further, two of the indo
The efficient synthesis of sugar-derived triazoles via a one-pot substitution-cyclization-oxidation procedure is presented. Starting from D-arabinose and L-fucose, triazole structures as potential enzyme inhibitors were obtained in six to eight steps.
## Abstract The condensation of protected and unprotected 3‐ketoglucose (1) with hydrazines to 4‐pyrazolols has been investigated. 3‐ (5) and 5‐(D‐__erythro__‐1,2,3‐trihydroxypropyl)‐4‐pyrazolol (4) were obtained from 1 in high yield, as a mixture of these two isomers. A regioselective route starti