Synthesis of isoxazolopyrroloisoquinolines by intramolecular cyclizations of 5-(2-arylethyl)-6-hydroxytetrahydro-4H-pyrrolo[3,4-d]isoxazol-4-ones
✍ Scribed by Alexander V. Stepakov; Maria S. Ledovskaya; Vitaly M. Boitsov; Alexander P. Molchanov; Rafael R. Kostikov; Vladislav V. Gurzhiy; Galina L. Starova
- Book ID
- 116909797
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 359 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The reduction of condensed imides 1 with sodium borohydride proceeds regio‐ and stereoselectively to yield the hydroxylactams 2, 3 and 4. AM1 calculations of the reactants and products reveal that the regiochemistry of the reductions seems to be controlled by both electronic and steric
## Abstract magnified image 2‐Methyl‐2,5,6,11,12,13‐hexahydro 4H indazolo[5,4‐a]pyrrolo[3,4‐c]carbazole‐4‐one was synthesized utilizing a regioselective Diels‐Alder reaction with 5‐(1H‐indol‐2‐yl)‐2‐methyl‐6,7‐dihydro‐2H‐indazole and ethyl __cis__‐β‐cyanoacrylate. Acetic acid and YtBr~3~ were the b