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Regioselective synthesis of 2-methyl-2,5,6,11,12,13-hexahydro 4H indazolo[5,4-a]pyrrolo[3,4-c]carbazole-4-ones

✍ Scribed by Ming Tao; Chung Ho Park; Kurt Josef; Robert L. Hudkins

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
109 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image 2‐Methyl‐2,5,6,11,12,13‐hexahydro 4H indazolo[5,4‐a]pyrrolo[3,4‐c]carbazole‐4‐one was synthesized utilizing a regioselective Diels‐Alder reaction with 5‐(1H‐indol‐2‐yl)‐2‐methyl‐6,7‐dihydro‐2H‐indazole and ethyl cis‐β‐cyanoacrylate. Acetic acid and YtBr~3~ were the best solvent and catalyst for the regioselective Diels‐Alder reaction. The chemistry was used to synthesize novel 8‐pyrimidinyloxy‐2,5,6,11,12,13‐hexahydro 4H indazolo[5,4‐a]pyrrolo[3,4‐c]carbazole‐4‐ones that were screened and found to be potent inhibitors of DLK. J. Heterocyclic Chem., (2009).

📜 SIMILAR VOLUMES

ChemInform Abstract: Regioselective Synt
ChemInform Abstract: Regioselective Synthesis of 2-Methyl-2,5,6,11,12,13-hexahydro 4H Indazolo[5,4-a]pyrrolo[3,4-c]carbazole-4-ones.
✍ Ming Tao; Chung Ho Park; Kurt Josef; Robert L. Hudkins 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 45 KB

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