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Synthesis of isotopically labelled glycyl-L-prolyl-L-glutamic acid (Glypromate®) and derivatives

✍ Scribed by Paul W. R. Harris; Margaret A. Brimble

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
161 KB
Volume
49
Category
Article
ISSN
0022-2135

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✦ Synopsis

The related tripeptides glycyl-l-prolyl-l-glutamic acid (GPE) and glycyl-l-2methylprolyl-l-glutamic acid (G-2-MePE) were labelled with commercially available [1,2,3,4,5-13 C 5 , 2-15 N 1 ]-l-glutamic acid in 3 steps in excellent overall yield with high isotope incorporation. A related cyclic dipeptide was labelled with [2,2-2 H 2 , 2-15 N 1 ]glycine giving a mixture of compounds resulting from deuterium scrambling.

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