๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Synthesis of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide gyrase B inhibitors

โœ Scribed by Christophe Peixoto; Patrick Laurin; Michel Klich; Claudine Dupuis-Hamelin; Pascale Mauvais; Patrice Lassaigne; Alain Bonnefoy; Branislav Musicki

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
168 KB
Volume
41
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

โœฆ Synopsis

The design, synthesis and in vitro biological evaluation of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide analogues of coumarin inhibitors of gyrase B are described. Compared to coumarin derivatives, compounds of the 1,2-benzooxathiin 2,2-dioxide series display improved inhibitory potency in negative supercoiling of relaxed DNA gyrase.

๐Ÿ“œ SIMILAR VOLUMES

Synthesis of 2-phosphoro-1,2-thiazetidin
Synthesis of 2-phosphoro-1,2-thiazetidine 1,1-dioxide
โœ Grazyna Mielniczak; Andrzej ลopusรญnski ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 209 KB ๐Ÿ‘ 2 views

The reactions of phosphorochloridites in the presence of triethylamine, affords the N-phosphitylated b-sultams 6a-b and L(โ€ซ8-)โ€ฌa,c. Their oxidation by addition of oxygen, sulfur, or selenium results in formation of stable organophosphorus b-sultams 10a-b, L(โ€ซ11-)โ€ฌa,c, 12a, 13a, L(โ€ซ41-)โ€ฌc, and L(โ€ซ51

Synthesis of cinnoline 1,2-dioxide
Synthesis of cinnoline 1,2-dioxide
โœ I. Suzuki; M. Nakadate; T. Nakashima; N. Nagasawa ๐Ÿ“‚ Article ๐Ÿ“… 1966 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 201 KB

Recently, Palmer and Russell (1) have reported that k-methylcinnoline afforded k-methylcinnol~ne 1,2-dioxide by the action of hydrogen peroxide and acetic acid, and the structure of the latter was elucidated by n.m.r., mass, W, IR spectrometry. We have also independently succeeded in the synthesis o

The 2B1 โ† 2A1 system of nitrogen dioxide
The 2B1 โ† 2A1 system of nitrogen dioxide
โœ J.L. Hardwick; J.C.D. Brand ๐Ÿ“‚ Article ๐Ÿ“… 1973 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 302 KB

The vibrational structure of the \*B1 + \*Al systc.m of NO% has been assigned to a progression in vi. Vibrational analyses for three isotopic species have been made using a hamiltonian which allows esplicitly fore largeamplitude bendingvibration. The system origin for the normal isotopic species ha