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Synthesis of Isomeric 6-Trifluoromethyl-3-azabicyclo[3.1.0]hexanes: Conformationally Restricted Analogues of 4-Trifluoromethylpiperidine

โœ Scribed by Artamonov, Olexiy; Slobodyanyuk, Evgeniy; Shishkin, Oleg; Komarov, Igor; Mykhailiuk, Pavel


Book ID
121667122
Publisher
Thieme Medical Publishers
Year
2012
Tongue
German
Weight
229 KB
Volume
45
Category
Article
ISSN
0039-7881

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## Novel Conversion of Perfluoro(2,6-dimethyl-1-azacyclohexene) to 3,3,4,4,5-Pentafluoro-2,6-diphenyl-2,6-bis (trifluoromethyl)-1azabicyclo[3.1.0]hexane. -Treatment of perfluoro-azacyclohexene (I) with 2 equiv. of phenyllithium (V) in a cyclohexane/Et 2 O mixture provides access to azabicyclohex