Synthesis of isoflavonoid deuterium labeled polyphenolic phytoestrogens
✍ Scribed by Sirpa Rasku; Kristiina Wähälä; Jorma Koskimies; Tapio Hase
- Book ID
- 108379197
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 553 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
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This paper describes the synthesis of deuterium‐labeled pregabalin. The stable isotopic‐labeled compound was obtained in nine steps starting from the commercially available 4‐[^2^H~11~]methylvaleric acid as the stable‐labeled reagent. It is used as an internal standard for analysis and metabolic stu
Several methods for the specific deuteration of cannabmoids are described. Deuteration of the phenolic ring was accomplished by treatment with BF, .Et10 followed by quenching with a solution of Na, CO, in Da 0 resulting in deuterium incorporation in both the 2 and 4 positions. Regioselective incorpo
## Abstract Ethyl isocyanate, N‐methylacetamide, N‐methylacetamide‐d3, and __N__‐methylacetamide‐d6 were reduced with lithium aluminum deuteride and then nitrosated with sodium nitrite to yield, respectively, nitrosomethyl (‐__d__3) ethylamine, nitrosomethylethyl (α‐**d2**) amine, nitrosomethylethy