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Synthesis of immunoglobulin by substrate attached mouse myeloma cells

✍ Scribed by Antonio Bargellesi; Guido Damiani; W. Michael Kuehl; Matthew D. Scharff

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
352 KB
Volume
88
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Cultured mouse myeloma cells grow in suspension and synthesize and secrete large amounts of immunoglobulin. Mouse myeloma cells which attach to a plastic substratum have been obtained by mutagenesis and subsequent selection. Normal mouse myeloma cells will also attach to plastic tissue culture dishes pre‐treated with poly‐L‐lysine. The attached cells synthesize and secrete the same large amounts of immunoglobulin as the suspended cells.

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