✦ LIBER ✦

Synthesis of imifuramine and its stereoisomers exhibiting histamine H3-agonistic activity

✍ Scribed by Shinya Harusawa; Tomonari Imazu; Seiichiroh Takashima; Lisa Araki; Hirofumi Ohishi; Takushi Kurihara; Yumiko Yamamoto; Atsushi Yamatodani

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 248 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00202-6

No coin nor oath required. For personal study only.

✦ Synopsis

The four possible stereoisomers of a novel imidazole C-nucleoside derivative were synthesized by the eJJ~cient use of a PhSe group. Among them, ( + )-4( 5)-[(2R,5R)-5-(aminomethyl)tetrahydrofuran-2-yl]imidazole (imifuramine) was indicated as a novel type of histamine Hj-agon/st by a brain microdialysis method.

📜 SIMILAR VOLUMES

Synthesis and histamine H3-receptor agon

Synthesis and histamine H3-receptor agonist activity of mono- and dialkyl-substituted histamine derivatives

✍ R Lipp; H Stark; JM Arrang; M Garbarg; JC Schwartz; W Schunack 📂 Article 📅 1995 🏛 Elsevier Science 🌐 French ⚖ 585 KB

Synthesis and in vitro pharmacology of d

Synthesis and in vitro pharmacology of dimaprit analogues with histamine H2-agonistic and H1-antagonistic activities

✍ JAM Christiaans; H van der Goot; WMPB Menge; H Timmerman 📂 Article 📅 1995 🏛 Elsevier Science 🌐 French ⚖ 615 KB

Synthesis and Histamine H3 and H4 Recept

Synthesis and Histamine H3 and H4 Receptor Activity of Conformationally Restricted Cyanoguanidines Related to UR-PI376

✍ Roland Geyer; Armin Buschauer 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 255 KB

ChemInform Abstract: Design, Synthesis,

ChemInform Abstract: Design, Synthesis, and Structure—Activity Relationships of Novel Non-Imidazole Histamine H3 Receptor Antagonists.

✍ Ian D. Linney; Ildiko M. Buck; Elaine A. Harper; S. Barret-Kalindjian; Michael J 📂 Article 📅 2000 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

ChemInform Abstract: Synthesis and Hista

ChemInform Abstract: Synthesis and Histamine H3 and H4 Receptor Activity of Conformationally Restricted Cyanoguanidines Related to UR-PI376.

✍ Roland Geyer; Armin Buschauer 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 22 KB

## Abstract It is shown that the quality of action of the synthesized compounds, their potency and receptor subtype selectivity depend on the stereochemistry.

ChemInform Abstract: Nα-Alkylated Deriva

ChemInform Abstract: Nα-Alkylated Derivatives of 2-Phenylhistamines: Synthesis and in vitro Activity of Potent Histamine H1-Receptor Agonists.

✍ K. KRAMER; S. ELZ; H. H. PERTZ; W. SCHUNACK 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

N α -Alkylated Derivatives of 2-Phenylhistamines: Synthesis and in vitro Activity of Potent Histamine H 1 -Receptor Agonists. -In vitro study of new potent histamine H 1 -receptor agonists, e.g. (V), shows that the derivative (Va) is the most potent compound described in the literature until now. -