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Synthesis and histamine H3-receptor agonist activity of mono- and dialkyl-substituted histamine derivatives

✍ Scribed by R Lipp; H Stark; JM Arrang; M Garbarg; JC Schwartz; W Schunack

Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
585 KB
Volume
30
Category
Article
ISSN
0223-5234

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The four possible stereoisomers of a novel imidazole C-nucleoside derivative were synthesized by the eJJ~cient use of a PhSe group. Among them, ( + )-4( 5)-[(2R,5R)-5-(aminomethyl)tetrahydrofuran-2-yl]imidazole (imifuramine) was indicated as a novel type of histamine Hj-agon/st by a brain microdialy