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Synthesis and in vitro pharmacology of dimaprit analogues with histamine H2-agonistic and H1-antagonistic activities

✍ Scribed by JAM Christiaans; H van der Goot; WMPB Menge; H Timmerman


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
615 KB
Volume
30
Category
Article
ISSN
0223-5234

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Design, synthesis, and pharmacological e
✍ Yasuyuki Kawanishi; Shoichi Ishihara; Tadahiko Tsushima; Kaoru Seno; Masanori Mi πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 436 KB

The joint type of hybrid molecules composed of two pharmacophore moieties taken from histamine H2 and gastrin receptor antagonists have been designed and synthesized to exhibit dual histamine H2 and gastrin receptor antagonistic activities. Here we report the importance of spacers as well as binding