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Synthesis of hydrazinopeptides using solid phase N-amination. Application to chemical ligation

✍ Scribed by Christine Kiinguer; Oleg Melnyk; Estelle Loing; Hélène Gras-Masse


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
188 KB
Volume
37
Category
Article
ISSN
0040-4039

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The synthesis of Boc-or Fmoc-monoprotected propylenediamine derivatives is reported starting from N-protected a-amino acids. The introduction of these building blocks on solid support via the formation of a urea moiety leads to a new pseudopeptide family (Ca-CHe-CH~-Na(R)-CO-NH-Ca). Two carbonylati