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Solid phase synthesis of Fmoc N-methyl amino acids: Application of the Fukuyama amine synthesis

✍ Scribed by Lihu Yang; Kuenley Chiu


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
229 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis


N-Methyl amino acids and their Fmoc derivatives are synthesized in high yield and purity on solid support using the Fukuyama amine synthesis protocol.


πŸ“œ SIMILAR VOLUMES


N-Fmoc-dehydroalanine: a versatile molec
✍ Brendan A Burkett; Christina L.L Chai πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 141 KB

The synthesis of polymer-supported N-Fmoc-dehydroalanine starting from S-protected cysteine via an oxidation/elimination strategy is described. Cycloaddition with a range of dienes aorded a range of conformationally constrained amino acids in moderate yields. The potential applications of this metho