The synthesis of Boc-or Fmoc-monoprotected propylenediamine derivatives is reported starting from N-protected a-amino acids. The introduction of these building blocks on solid support via the formation of a urea moiety leads to a new pseudopeptide family (Ca-CHe-CH~-Na(R)-CO-NH-Ca). Two carbonylati
Solid phase synthesis of unsymmetrical secondary amines—Application to the synthesis of arylethanolamines and arylpropanolamines
✍ Scribed by Ashok V Purandare; Michael A. Poss
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 222 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A novel and simple solid phase synthesis ofunsymme~cal secondary amines was developed. The general methodology was applied to the synthesis of arylethanolamines and arylpropanolamines.
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