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Synthesis of high specific activity tritium-labelled chloroethylcyclohexylnitrosourea and its application to the study of dna modification

✍ Scribed by Ernest L. Siew; Yvette Habraken; David B. Ludlum

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
286 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

A small-scale synthesis of high specific activity, N-(2-chloro-2-[3H]-ethyl)-N'-cyclohexyl-N-nitrosourea ([3H]-CCNU) has been accomplished from tritium-labelled ethanolamine. The product is pure by TLC and HPLC analysis and has been used successfully to modify DNA. The overall yield on radioactivity including losses in HPLC purification is approximately 4 percent. The availability of this tritiumlabelled compound makes studies of DNA repair and of cellular resistance to N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea possible.

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