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Synthesis of Hexadecylphospho[methyl-14C]-choline

✍ Scribed by C. C. Geilen; A. Samson; Th. Wieder; H. Wild; W. Reutter

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
216 KB
Volume
31
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Hexadecylphospho[methyl‐^14^C]‐choline was synthesized in two steps from the tetra‐n‐butyl‐ammonium salt of phosphoryl[methyl‐^14^C]‐choline and 1‐bromohexadecane, and purified by column chromatography on silica gel. The total yield of the radioactive synthesis was 35%, whereas the total yield of the non‐radioactive synthesis was 40%. Hexadecylphospho[methyl‐^14^C]‐choline may serve as a useful tool for pharmacokinetic and biochemical studies of this new antitumor drug.

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