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Synthesis of heparin fragments: A methyl α-pentaoside with high affinity for antithrombin III

✍ Scribed by Maurice Petitou; Philippe Duchaussoy; Isidore Lederman; Jean Choay; Jean-Claude Jacquinet; Pierre Sinaÿ; Giangiacomo Torri


Book ID
107725660
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
591 KB
Volume
167
Category
Article
ISSN
0008-6215

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Total synthesis of a heparin pentasaccha
✍ Pierre Sinaÿ; Jean-Claude Jacquinet; Maurice Petitou; Philippe Duchaussoy; Isido 📂 Article 📅 1984 🏛 Elsevier Science 🌐 English ⚖ 254 KB

Heparin is a sulfated glucosaminoglycan with a well-known anticoagulant activity' , and the active molecules have a high affinity for antithrombin III (AT-III), thereby enhancing the effects of this inhibitor on procoagulant proteases. The structures of highaffinity oligosaccharides, prepared from h