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ChemInform Abstract: 3α-Hydroxy-3β-(phenylethynyl)-5β-pregnan-20-ones: Synthesis and Pharmacological Activity of Neuroactive Steroids with High Affinity for GABAA Receptors.

✍ Scribed by R. B. UPASANI; K. C. YANG; M. ACOSTA-BURRUEL; C. S. KONKOY; J. A. MCLELLAN; R. M. WOODWARD; N. C. LAN; R. B. CARTER; J. E. HAWKINSON


Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
28
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and in vi
✍ D. J. HOGENKAMP; S. H. TAHIR; J. E. HAWKINSON; R. B. UPASANI; M. ALAUDDIN; C. L. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB

Synthesis and in vitro Activity of 3β-Substituted-3α-hydroxypregnan-20-ones: Allosteric Modulators of the GABAA Receptor. -A series of 3β-substituted 3α-hydroxy-5α-(24 examples) and -5β-pregnan-20-ones (7 examples) is evaluated as potent allosteric modulators for the γ-aminobutyric acidA (GABAA) re