ChemInform Abstract: Synthesis and in vi
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D. J. HOGENKAMP; S. H. TAHIR; J. E. HAWKINSON; R. B. UPASANI; M. ALAUDDIN; C. L.
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Article
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2010
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John Wiley and Sons
⚖ 36 KB
Synthesis and in vitro Activity of 3β-Substituted-3α-hydroxypregnan-20-ones: Allosteric Modulators of the GABAA Receptor. -A series of 3β-substituted 3α-hydroxy-5α-(24 examples) and -5β-pregnan-20-ones (7 examples) is evaluated as potent allosteric modulators for the γ-aminobutyric acidA (GABAA) re