Total synthesis of a heparin pentasaccha
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Pierre SinaΓΏ; Jean-Claude Jacquinet; Maurice Petitou; Philippe Duchaussoy; Isido
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Article
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1984
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Elsevier Science
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English
β 254 KB
Heparin is a sulfated glucosaminoglycan with a well-known anticoagulant activity' , and the active molecules have a high affinity for antithrombin III (AT-III), thereby enhancing the effects of this inhibitor on procoagulant proteases. The structures of highaffinity oligosaccharides, prepared from h