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Synthesis of a heparin pentasaccharide fragment with a high affinity for antithrombin III employing cellobiose as a key starting material

✍ Scribed by Yoshitaka Ichikawa; Ryuji Monden; Hiroyoshi Kuzuhara


Book ID
104218168
Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
225 KB
Volume
27
Category
Article
ISSN
0040-4039

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Total synthesis of a heparin pentasaccha
✍ Pierre SinaΓΏ; Jean-Claude Jacquinet; Maurice Petitou; Philippe Duchaussoy; Isido πŸ“‚ Article πŸ“… 1984 πŸ› Elsevier Science 🌐 English βš– 254 KB

Heparin is a sulfated glucosaminoglycan with a well-known anticoagulant activity' , and the active molecules have a high affinity for antithrombin III (AT-III), thereby enhancing the effects of this inhibitor on procoagulant proteases. The structures of highaffinity oligosaccharides, prepared from h