Synthesis of glutamate agonists and anatagonists by a ring switching strategy
✍ Scribed by Andrew Dinsmore; Paul M. Doyle; Douglas W. Young
- Book ID
- 103406417
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 306 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The activated b-lactam aldehydes 31 and 55 were synthesised and found to be excellent substrates for our 'ring switching' strategy for preparation of libraries of homochiral compounds with potential for activity at specific glutamate receptor sub-types. The product heteroaromatic glycine derivatives
## Abstract magnified image A new ring‐switching reaction of enaminoesters behaving as bisnucleophiles towards other enaminoesters behaving as biselectrophiles is described. By starting from pyroglutamic derivatives, this reaction provided easy access to methyl 5‐oxo‐1,2,3,5‐tetrahydro‐3‐indolizin