Synthesis of condensed pyridones by using a new ring switching reaction

✍ Scribed by Thierry Brunin; Benoît Rigo; Jean-Pierre Hénichart

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2008
• Tongue: English
• Weight: 265 KB
• Volume: 45
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570450548

✦ Synopsis

Abstract

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A new ring‐switching reaction of enaminoesters behaving as bisnucleophiles towards other enaminoesters behaving as biselectrophiles is described. By starting from pyroglutamic derivatives, this reaction provided easy access to methyl 5‐oxo‐1,2,3,5‐tetrahydro‐3‐indolizinecarboxylates substituted by an aminoester side chain in position 6.