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Synthesis of glucose-3 and -4-14C of high specific activity and radiochemical purity

✍ Scribed by E. Sturani

Publisher: John Wiley and Sons
Year: 1969
Tongue: French
Weight: 388 KB
Volume: 5
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2590050108

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✦ Synopsis

A method for the enzymatic synthesis of hexoses-3-14C and hexoses-4-14C is presented. The procedure is based on the synthesis of 3-phosphoglyceric acid-1-1% (3PGA) by the action of the ribulose diphosphate carboxylase in the presence of ribulose-l,5 diphosphate and W 0 2 , followed by the reversal of the glycolytic reactions leading from glucose to 3PGA. For the synthesis of hexoses-3-14CC, dihydroxyacetonephosphate-1-14C and cold glyceraldehyde-3-P are condensed by the aldolase reaction, while for the synthesis oJ hexoses-4-14C cold dihydroxyacetonephosphate is condensed with glyceraldehyde-3-P-l-14C. The problems and the results of such syntheses are discussed.

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