Synthesis of fused pyran-carbahexopyranoses as glycosidase inhibitors
β Scribed by Venkata Ramana Doddi; Pavan K. Kancharla; Y. Suman Reddy; Amit Kumar; Yashwant D. Vankar
- Book ID
- 108080607
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 383 KB
- Volume
- 344
- Category
- Article
- ISSN
- 0008-6215
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π SIMILAR VOLUMES
Several polyhydroxylated pyrrolidines with an aliphatic long chain on the ring nitrogen were prepared starting from D-mannitol. An amphiphilic bis-azasugar scaffold has been also prepared. These products behave as cationic surfactants and show a promising anti HIV-1 activity.
## Abstract Two pyrrolidineβbased imino sugars have been synthesized in an efficient manner, using regiospecific amination, ring closing metathesis, and diastereospecific dihydroxylations as key steps. These azasugars are found to be moderate inhibitors of glycosidases. (Β© WileyβVCH Verlag GmbH & C