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Synthesis of Fmoc-protected amino ketones bearing tert-butyl based side-chain protecting groups

✍ Scribed by Jesús Vázquez; Fernando Albericio


Book ID
104252058
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
149 KB
Volume
43
Category
Article
ISSN
0040-4039

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## Abstract The sequence‐dependent, acid‐ or base‐catalysed aspartimide formation is one of the most serious side reactions in solid‐phase synthesis of peptides containing aspartic acid. In the present work, we investigated the susceptibility of 4‐{__N__‐[1‐(4,4‐dimethyl‐2,6‐dioxocyclohexylidene)‐3