Hydrogen fluoride catalyzed migration of side chain protecting groups onto Fmoc during solid phase peptide synthesis

Problem of aspartimide formation in Fmoc

Problem of aspartimide formation in Fmoc-based solid-phase peptide synthesis using Dmab group to protect side chain of aspartic acid

✍ JarosŁaw Ruczyński; Brygida Lewandowska; Piotr Mucha; Piotr Rekowski 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 132 KB

## Abstract The sequence‐dependent, acid‐ or base‐catalysed aspartimide formation is one of the most serious side reactions in solid‐phase synthesis of peptides containing aspartic acid. In the present work, we investigated the susceptibility of 4‐{__N__‐[1‐(4,4‐dimethyl‐2,6‐dioxocyclohexylidene)‐3